A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation
Abstract Background Neurons assemble into a functional network through a sequence of developmental processes including neuronal polarization and synapse formation.In Caenorhabditis elegans, the serine/threonine SAD-1 kinase is essential for fleshlight automatique proper neuronal polarity and synaptic organization.To determine if SAD-1 activity regu